Homo sapiens Protein: RBPMS2
Summary
InnateDB Protein IDBP-596478.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol RBPMS2
Protein Name RNA binding protein, mRNA processing factor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000300069
InnateDB Gene IDBG-117103 (RBPMS2)
Protein Structure
UniProt Annotation
Function Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation. {ECO:0000250UniProtKB:Q9W6I1}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:25064856}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007275 multicellular organism development
GO:0030514 negative regulation of BMP signaling pathway
GO:0048557 embryonic digestive tract morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051151 negative regulation of smooth muscle cell differentiation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR034787 RBPMS2, RNA recognition motif
IPR035979 RNA-binding domain superfamily
PFAM PF00076
PF16367
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZRY4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 348093
UniGene
RefSeq NP_919248
HUGO HGNC:19098
OMIM
CCDS CCDS32271
HPRD
IMGT
EMBL AC091582 AC100830 AK127873 AY369207 BC131612
GenPept AAI31613 AAQ73311 BAC87172