InnateDB Protein
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IDBP-596723.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTH
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Protein Name
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parathyroid hormone
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Synonyms
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PTH1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433208
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InnateDB Gene
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IDBG-32891 (PTH)
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Protein Structure
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Function |
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. {ECO:0000269PubMed:21076856}.
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Subcellular Localization |
Secreted.
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Disease Associations |
Hypoparathyroidism, familial isolated (FIH) [MIM:146200]: A disorder characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Clinical features include seizures, tetany and cramps. {ECO:0000269PubMed:10523031, ECO:0000269PubMed:2212001}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003705
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RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
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GO:0005179
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hormone activity
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GO:0051428
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peptide hormone receptor binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001501
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skeletal system development
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0008628
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hormone-mediated apoptotic signaling pathway
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GO:0010468
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regulation of gene expression
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GO:0030501
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positive regulation of bone mineralization
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GO:0030819
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positive regulation of cAMP biosynthetic process
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GO:0034645
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cellular macromolecule biosynthetic process
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GO:0045453
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bone resorption
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GO:0045725
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positive regulation of glycogen biosynthetic process
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0046058
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cAMP metabolic process
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GO:0046326
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positive regulation of glucose import
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Cellular Component |
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PDB ID |
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InterPro |
IPR001415
Parathyroid hormone/parathyroid hormone-related protein
IPR003625
Parathyroid hormone
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PFAM |
PF01279
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PRINTS |
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PIRSF |
PIRSF001832
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SMART |
SM00087
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TIGRFAMs |
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Modification |
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SwissProt |
P01270
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PhosphoSite |
PhosphoSite-P01270
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5741
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UniGene |
Hs.37045
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RefSeq |
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HUGO |
HGNC:9606
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OMIM |
168450
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CCDS |
CCDS7812
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HPRD |
01345
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IMGT |
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EMBL |
BC096142
BC096143
BC096144
BC096145
J00301
V00597
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GenPept |
AAA60215
AAH96142
AAH96143
AAH96144
AAH96145
CAA23843
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