InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBTB33

Summary

InnateDB Protein

IDBP-596787.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBTB33

Protein Name

transcriptional regulator Kaiso

Synonyms

ZNF-kaiso; ZNF348;

Species

Homo sapiens

Ensembl Protein

ENSP00000450969

InnateDB Gene

IDBG-84309 (ZBTB33)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. {ECO:0000269PubMed:11445535, ECO:0000269PubMed:14527417, ECO:0000269PubMed:15548582, ECO:0000269PubMed:15817151}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15781635}. Cytoplasm {ECO:0000269PubMed:15781635}. Note=Also cytoplasmic in cells grown at high densities.

Disease Associations

Tissue Specificity

Expressed in vascular endothelium. {ECO:0000269PubMed:14699141}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	23 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008327	methyl-CpG binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016055	Wnt signaling pathway
GO:0035556	intracellular signal transduction
GO:0045892	negative regulation of transcription, DNA-templated