Version 5.4
Homo sapiens Protein: DND1
Summary
InnateDB Protein IDBP-596788.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DND1
Protein Name dead end homolog 1 (zebrafish)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000445366
InnateDB Gene IDBG-547469 (DND1)
Protein Structure
UniProt Annotation
Function RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:18155131}. Cytoplasm {ECO:0000269PubMed:18155131}. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0017091 AU-rich element binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007281 germ cell development
GO:0060965 negative regulation of gene silencing by miRNA
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IYX4
PhosphoSite PhosphoSite-Q8IYX4
TrEMBL
UniProt Splice Variant
Entrez Gene 373863
UniGene Hs.741051
RefSeq NP_919225
HUGO HGNC:23799
OMIM 609385
CCDS CCDS4236
HPRD 13240
IMGT
EMBL AY321065 BC033496
GenPept AAH33496 AAQ63635

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca