InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAPGEF4

Summary

InnateDB Protein

IDBP-596830.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF4

Protein Name

Rap guanine nucleotide exchange factor (GEF) 4

Synonyms

2; CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2; Nbla00496;

Species

Homo sapiens

Ensembl Protein

ENSP00000440250

InnateDB Gene

IDBG-75192 (RAPGEF4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0017016	Ras GTPase binding
GO:0030552	cAMP binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0044281	small molecule metabolic process
GO:0045859	regulation of protein kinase activity
GO:0050796	regulation of insulin secretion
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005952	cAMP-dependent protein kinase complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000591 DEP domain
IPR000595 Cyclic nucleotide-binding domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR018490 Cyclic nucleotide-binding-like
IPR023578 Ras guanine nucleotide exchange factor domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00610
PF00027
PF00618
PF00617

PRINTS

PR00103

PIRSF

SMART

SM00314
SM00049
SM00100
SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt