InnateDB Protein
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IDBP-596854.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CELF5
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Protein Name
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CUGBP, Elav-like family member 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000443498
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InnateDB Gene
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IDBG-17029 (CELF5)
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Protein Structure
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Function |
RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269PubMed:11158314}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain. {ECO:0000269PubMed:11158314}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N6W0
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PhosphoSite |
PhosphoSite-Q8N6W0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
60680
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UniGene |
Hs.655747
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RefSeq |
NP_001166144
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HUGO |
HGNC:14058
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OMIM |
612680
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CCDS |
CCDS54197
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HPRD |
12535
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IMGT |
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EMBL |
AB209067
AC005331
AC006505
AC010649
AC123911
AF248649
AF329266
BC028101
CH471139
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GenPept |
AAC27666
AAF86231
AAH28101
AAK07476
BAD92304
EAW69327
EAW69328
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