InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYNE3

Summary

InnateDB Protein

IDBP-596895.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNE3

Protein Name

chromosome 14 open reading frame 49

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000450562

InnateDB Gene

IDBG-18660 (SYNE3)

Protein Structure

UniProt Annotation

Function

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells. {ECO:0000269PubMed:16330710, ECO:0000269PubMed:18396275, ECO:0000269PubMed:21937718}.

Subcellular Localization

Nucleus outer membrane {ECO:0000269PubMed:21937718}; Single-pass type IV membrane protein {ECO:0000269PubMed:21937718}. Nucleus envelope {ECO:0000269PubMed:21937718}. Rough endoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in aortic endothelial cells (at protein level). {ECO:0000269PubMed:21937718}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0090150	establishment of protein localization to membrane
GO:0090286	cytoskeletal anchoring at nuclear membrane

Cellular Component

GO:0005635	nuclear envelope
GO:0005640	nuclear outer membrane
GO:0005791	rough endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0034993	SUN-KASH complex