InnateDB Protein
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IDBP-596970.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BID
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Protein Name
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BH3 interacting domain death agonist
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Synonyms
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FP497;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000449236
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InnateDB Gene
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IDBG-1050 (BID)
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Protein Structure
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Function |
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250, ECO:0000269PubMed:14583606}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Mitochondrion membrane {ECO:0000250}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269PubMed:14583606}.BH3-interacting domain death agonist p15: Mitochondrion membrane {ECO:0000250}. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250}.BH3-interacting domain death agonist p13: Mitochondrion membrane {ECO:0000250}. Note=Associated with the mitochondrial membrane. {ECO:0000250}.Isoform 1: Cytoplasm.Isoform 3: Cytoplasm.Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.
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Disease Associations |
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Tissue Specificity |
Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). {ECO:0000269PubMed:14583606}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
99
[view]
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Protein-Protein |
97
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0001836
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release of cytochrome c from mitochondria
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GO:0006915
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apoptotic process
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GO:0008625
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extrinsic apoptotic signaling pathway via death domain receptors
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GO:0008637
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apoptotic mitochondrial changes
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GO:0032461
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positive regulation of protein oligomerization
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GO:0032464
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positive regulation of protein homooligomerization
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GO:0042770
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signal transduction in response to DNA damage
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GO:0043065
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positive regulation of apoptotic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0051402
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neuron apoptotic process
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GO:0090150
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establishment of protein localization to membrane
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GO:0090200
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positive regulation of release of cytochrome c from mitochondria
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GO:0097193
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intrinsic apoptotic signaling pathway
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GO:1900740
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positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
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GO:1901030
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positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
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GO:2001238
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positive regulation of extrinsic apoptotic signaling pathway
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GO:2001244
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positive regulation of intrinsic apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR010479
BH3 interacting
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PFAM |
PF06393
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PRINTS |
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PIRSF |
PIRSF038018
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P55957
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PhosphoSite |
PhosphoSite-P55957
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TrEMBL |
B2ZP79
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UniProt Splice Variant |
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Entrez Gene |
637
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UniGene |
Hs.591054
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RefSeq |
NP_001231496
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HUGO |
HGNC:1050
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OMIM |
601997
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CCDS |
CCDS13748
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HPRD |
03590
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IMGT |
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EMBL |
AF042083
AF087891
AF250233
AK313729
AY005151
AY309922
BC009197
BC022072
BC033634
BC036364
CH471193
CR407603
CR456389
D89803
EU447348
EU678293
EU678294
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GenPept |
AAC34365
AAF89091
AAH09197
AAH22072
AAH33634
AAH36364
AAO32633
AAP50259
AAP97190
ACA61804
ACD47107
ACD47108
BAF79673
BAG36471
CAG28531
CAG30275
EAW57771
EAW57773
EAW57774
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