Version 5.4
Homo sapiens Protein: TLX1
Summary
InnateDB Protein IDBP-596992.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLX1
Protein Name T-cell leukemia homeobox 1
Synonyms HOX11; TCL3;
Species Homo sapiens
Ensembl Protein ENSP00000434914
InnateDB Gene IDBG-87034 (TLX1)
Protein Structure
UniProt Annotation
Function Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31314
PhosphoSite PhosphoSite-P31314
TrEMBL
UniProt Splice Variant
Entrez Gene 3195
UniGene
RefSeq NP_001182446
HUGO HGNC:5056
OMIM 186770
CCDS CCDS55725
HPRD 01728
IMGT
EMBL AF067443 AJ009794 AL357395 BC130530 CH471066 M62626 M75952 S38742
GenPept AAA36719 AAA58662 AAB19293 AAG10096 AAI30531 CAA08834 CAH72448 EAW49778

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca