InnateDB Protein
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IDBP-597037.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LETMD1
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Protein Name
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LETM1 domain containing 1
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Synonyms
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1110019O13Rik; HCCR-1; HCCR-2; HCCR1; HCRR-2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000450163
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InnateDB Gene
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IDBG-32999 (LETMD1)
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Protein Structure
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Function |
Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. {ECO:0000269PubMed:12879013}.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000269PubMed:17943721, ECO:0000269PubMed:18045496}; Single-pass membrane protein {ECO:0000269PubMed:17943721, ECO:0000269PubMed:18045496}.
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Disease Associations |
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Tissue Specificity |
Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix. {ECO:0000269PubMed:12879013}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011685
LETM1-like
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PFAM |
PF07766
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P1Q0
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PhosphoSite |
PhosphoSite-Q6P1Q0
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TrEMBL |
F8VR33
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UniProt Splice Variant |
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Entrez Gene |
25875
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UniGene |
Hs.655272
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RefSeq |
XP_006719402
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HUGO |
HGNC:24241
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OMIM |
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CCDS |
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HPRD |
09978
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IMGT |
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EMBL |
AC087884
AF195651
AF315598
AF329277
AK127540
AL050286
AY259835
AY259836
BC000395
BC019274
BC064943
CH471111
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GenPept |
AAH00395
AAH19274
AAH64943
AAK34885
AAL26878
AAL56993
AAP85624
AAP85625
BAG54519
CAB43387
EAW58167
EAW58169
EAW58170
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