InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AHR

Summary

InnateDB Protein

IDBP-597224.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AHR

Protein Name

aryl hydrocarbon receptor

Synonyms

bHLHe76;

Species

Homo sapiens

Ensembl Protein

ENSP00000436466

InnateDB Gene

IDBG-8995 (AHR)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. {ECO:0000269PubMed:10395741, ECO:0000269PubMed:7961644}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Disease Associations

Tissue Specificity

Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. {ECO:0000269PubMed:7515333, ECO:0000269PubMed:8246913}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	56 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035326	enhancer binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0051879	Hsp90 protein binding
GO:0070888	E-box binding

Biological Process

GO:0001568	blood vessel development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006805	xenobiotic metabolic process
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0009410	response to xenobiotic stimulus
GO:0010468	regulation of gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0030888	regulation of B cell proliferation
GO:0032922	circadian regulation of gene expression
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated