InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PEBP1

Summary

InnateDB Protein

IDBP-59732.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEBP1

Protein Name

phosphatidylethanolamine binding protein 1

Synonyms

HCNP; HCNPpp; HEL-210; HEL-S-34; PBP; PEBP; PEBP-1; RKIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000261313

InnateDB Gene

IDBG-59730 (PEBP1)

Protein Structure

UniProt Annotation

Function

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269PubMed:18294816}.HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008429	phosphatidylethanolamine binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding