InnateDB Protein
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IDBP-597359.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KIAA1324
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Protein Name
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KIAA1324
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000434595
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InnateDB Gene
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IDBG-100781 (KIAA1324)
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Protein Structure
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Function |
May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. {ECO:0000269PubMed:21072319}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269PubMed:21072319}. Late endosome membrane {ECO:0000269PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269PubMed:21072319}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269PubMed:21072319}. Lysosome membrane {ECO:0000269PubMed:21072319}; Single-pass membrane protein {ECO:0000269PubMed:21072319}.
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Disease Associations |
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Tissue Specificity |
Expressed in normal endometrium but overexpressed in endometroid tumors. {ECO:0000269PubMed:16322283}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0009267
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cellular response to starvation
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GO:0016236
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macroautophagy
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GO:0044090
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positive regulation of vacuole organization
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GO:2000786
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positive regulation of autophagic vacuole assembly
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GO:2001240
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negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Cellular Component |
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PDB ID |
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InterPro |
IPR009011
Mannose-6-phosphate receptor binding domain
IPR009030
Insulin-like growth factor binding protein, N-terminal
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6UXG2
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PhosphoSite |
PhosphoSite-Q6UXG2
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TrEMBL |
E9PS21
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UniProt Splice Variant |
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Entrez Gene |
57535
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UniGene |
Hs.739368
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RefSeq |
NP_001253977
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HUGO |
HGNC:29618
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OMIM |
611298
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CCDS |
CCDS58015
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HPRD |
13850
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IMGT |
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EMBL |
AB037745
AL138933
AL356389
AY358366
BC125208
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GenPept |
AAI25209
AAQ88732
BAA92562
CAI13596
CAI13597
CAI13598
CAI22280
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