InnateDB Protein
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IDBP-597699.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGBL5
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Protein Name
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ATP/GTP binding protein-like 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433830
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InnateDB Gene
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IDBG-36560 (AGBL5)
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Protein Structure
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Function |
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000834
Peptidase M14, carboxypeptidase A
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PFAM |
PF00246
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PRINTS |
PR00765
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PIRSF |
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SMART |
SM00631
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NDL9
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PhosphoSite |
PhosphoSite-Q8NDL9
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TrEMBL |
C9JTY1
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UniProt Splice Variant |
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Entrez Gene |
60509
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UniGene |
Hs.138207
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RefSeq |
XP_006712121
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HUGO |
HGNC:26147
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OMIM |
615900
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CCDS |
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HPRD |
07968
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IMGT |
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EMBL |
AC013403
AC013472
AK023398
AK025492
AK302091
AL833844
BC007415
BC018584
BC131498
CH471053
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GenPept |
AAH07415
AAI31499
AAX93164
AAY14655
BAB14560
BAB15151
BAH13623
CAD38704
EAX00649
EAX00651
EAX00652
EAX00653
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