InnateDB Protein
|
IDBP-597832.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CDC42SE1
|
Protein Name
|
CDC42 small effector 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000445647
|
InnateDB Gene
|
IDBG-102279 (CDC42SE1)
|
Protein Structure
|
|
Function |
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269PubMed:10816584, ECO:0000269PubMed:15840583, ECO:0000269PubMed:17045588}.
|
Subcellular Localization |
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Recruited to the activated TCR prior actin polymerization.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. Expressed at higher level in T-lymphocytes, dendritic and whole blood cells. {ECO:0000269PubMed:15840583}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
0
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005095
|
GTPase inhibitor activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000095
CRIB domain
|
PFAM |
PF00786
|
PRINTS |
|
PIRSF |
|
SMART |
SM00285
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NRR8
|
PhosphoSite |
PhosphoSite-Q9NRR8
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
56882
|
UniGene |
Hs.22065
|
RefSeq |
NP_001033796
|
HUGO |
HGNC:17719
|
OMIM |
|
CCDS |
CCDS981
|
HPRD |
16694
|
IMGT |
|
EMBL |
AF187845
AF286041
AF286592
AL590133
BC012796
BC041604
CH471121
|
GenPept |
AAF87597
AAF97248
AAG17723
AAH12796
AAH41604
CAI13349
EAW53477
EAW53478
EAW53479
|
|
|