InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CREBZF

Summary

InnateDB Protein

IDBP-597881.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREBZF

Protein Name

CREB/ATF bZIP transcription factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000434281

InnateDB Gene

IDBG-66455 (CREBZF)

Protein Structure

UniProt Annotation

Function

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269PubMed:10871379, ECO:0000269PubMed:15705566}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15705566}. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.

Disease Associations

Tissue Specificity

In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver. {ECO:0000269PubMed:10871379}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009615	response to virus
GO:0045814	negative regulation of gene expression, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity