InnateDB Protein
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IDBP-59806.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LMAN2
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Protein Name
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lectin, mannose-binding 2
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Synonyms
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C5orf8; GP36B; VIP36;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000303366
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InnateDB Gene
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IDBG-59804 (LMAN2)
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Protein Structure
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Function |
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269PubMed:10444376}. Golgi apparatus membrane {ECO:0000269PubMed:10444376}; Single-pass membrane protein {ECO:0000269PubMed:10444376}. Endoplasmic reticulum membrane {ECO:0000269PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269PubMed:10444376}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005052
Legume-like lectin
IPR008985
Concanavalin A-like lectin/glucanases superfamily
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PFAM |
PF03388
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q12907
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PhosphoSite |
PhosphoSite-Q12907
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TrEMBL |
D6RIU4
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UniProt Splice Variant |
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Entrez Gene |
10960
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UniGene |
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RefSeq |
NP_006807
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HUGO |
HGNC:16986
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OMIM |
609551
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CCDS |
CCDS4417
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HPRD |
17285
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IMGT |
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EMBL |
AC146507
AK222609
AK301607
BC017263
U10362
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GenPept |
AAA19572
AAH17263
BAD96329
BAG63093
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