InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST2

Summary

InnateDB Protein

IDBP-59829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST2

Protein Name

carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2

Synonyms

C6ST; glcNAc6ST-1; Gn6ST-1; GST-2; GST2; HEL-S-75;

Species

Homo sapiens

Ensembl Protein

ENSP00000307911

InnateDB Gene

IDBG-59827 (CHST2)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269PubMed:11042394}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:12855678, ECO:0000269PubMed:22260995}; Single-pass type II membrane protein {ECO:0000269PubMed:12855678, ECO:0000269PubMed:22260995}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269PubMed:10049591, ECO:0000269PubMed:11310842, ECO:0000269PubMed:9722682}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0006790	sulfur compound metabolic process
GO:0006954	inflammatory response
GO:0007275	multicellular organismal development
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0044281	small molecule metabolic process