Version 5.4
Homo sapiens Protein: FOXN3
Summary
InnateDB Protein IDBP-598319.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXN3
Protein Name forkhead box N3
Synonyms C14orf116; CHES1; PRO1635;
Species Homo sapiens
Ensembl Protein ENSP00000452227
InnateDB Gene IDBG-15491 (FOXN3)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269PubMed:16102918}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000085 mitotic G2 phase
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001766 Transcription factor, fork head
PFAM PF00250
PRINTS PR00053
PIRSF
SMART SM00339
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00409
PhosphoSite PhosphoSite-O00409
TrEMBL G3V5C7
UniProt Splice Variant
Entrez Gene 1112
UniGene Hs.621371
RefSeq
HUGO HGNC:1928
OMIM 602628
CCDS CCDS32138
HPRD 07533
IMGT
EMBL AC007263 AL137230 AL137785 AL138478 AL157736 AL163032 AL356805 AL357093 BC007506 U68723
GenPept AAB58252 AAF18259 AAH07506

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca