InnateDB Protein
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IDBP-598353.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNF182
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Protein Name
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ring finger protein 182
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000442021
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InnateDB Gene
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IDBG-62694 (RNF182)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. {ECO:0000269PubMed:18298843}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:18298843}.
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Disease Associations |
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Tissue Specificity |
Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains. {ECO:0000269PubMed:18298843}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
IPR018957
Zinc finger, C3HC4 RING-type
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PFAM |
PF13639
PF14634
PF00097
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N6D2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
C9JVS8
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UniProt Splice Variant |
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Entrez Gene |
221687
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UniGene |
Hs.111164
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RefSeq |
NP_001158504
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HUGO |
HGNC:28522
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OMIM |
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CCDS |
CCDS4531
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HPRD |
15264
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IMGT |
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EMBL |
AK090576
AK315528
AL138718
BC030666
BC050030
CH471087
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GenPept |
AAH30666
AAH50030
BAC03481
BAG37909
EAW55349
EAW55350
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