InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC19A1

Summary

InnateDB Protein

IDBP-598472.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC19A1

Protein Name

solute carrier family 19 (folate transporter), member 1

Synonyms

CHMD; FOLT; IFC1; REFC; RFC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000441772

InnateDB Gene

IDBG-5929 (SLC19A1)

Protein Structure

UniProt Annotation

Function

Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Placenta, liver, and to a much smaller extent, in lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005542	folic acid binding
GO:0008517	folic acid transporter activity
GO:0015350	methotrexate transporter activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0015884	folic acid transport
GO:0044281	small molecule metabolic process
GO:0046655	folic acid metabolic process
GO:0051958	methotrexate transport