InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAOK2

Summary

InnateDB Protein

IDBP-598489.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAOK2

Protein Name

TAO kinase 2

Synonyms

MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;

Species

Homo sapiens

Ensembl Protein

ENSP00000440336

InnateDB Gene

IDBG-25151 (TAOK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001558	regulation of cell growth
GO:0006468	protein phosphorylation
GO:0006612	protein targeting to membrane
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0006974	cellular response to DNA damage stimulus
GO:0008360	regulation of cell shape
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0031572	G2 DNA damage checkpoint
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0046330	positive regulation of JNK cascade
GO:0048041	focal adhesion assembly
GO:0051403	stress-activated MAPK cascade

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030425	dendrite
GO:0030659	cytoplasmic vesicle membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt