InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTR

Summary

InnateDB Protein

IDBP-598637.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTR

Protein Name

5-methyltetrahydrofolate-homocysteine methyltransferase

Synonyms

cblG; HMAG; MS;

Species

Homo sapiens

Ensembl Protein

ENSP00000441845

InnateDB Gene

IDBG-107637 (MTR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008705	methionine synthase activity
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity
GO:0031419	cobalamin binding
GO:0046872	metal ion binding

Biological Process

GO:0009086	methionine biosynthetic process
GO:0032259	methylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000489 Pterin-binding
IPR003726 Homocysteine S-methyltransferase
IPR003759 Cobalamin (vitamin B12)-binding module, cap domain
IPR004223 Vitamin B12-dependent methionine synthase, activation domain
IPR006158 Cobalamin (vitamin B12)-binding domain
IPR011005 Dihydropteroate synthase-like
IPR011822 Cobalamin-dependent methionine synthase

PFAM

PF00809
PF02574
PF02607
PF02965
PF02310

PRINTS

PIRSF

PIRSF000381

SMART

SM01018

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt