InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACTN4

Summary

InnateDB Protein

IDBP-598664.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTN4

Protein Name

actinin, alpha 4

Synonyms

ACTININ-4; FSGS; FSGS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000439497

InnateDB Gene

IDBG-49384 (ACTN4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	91 [view]
Protein-Protein	91 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001882	nucleoside binding
GO:0003779	actin binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0002576	platelet degranulation
GO:0007596	blood coagulation
GO:0015031	protein transport
GO:0030168	platelet activation
GO:0032417	positive regulation of sodium:proton antiporter activity
GO:0042981	regulation of apoptotic process
GO:0051272	positive regulation of cellular component movement

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0031093	platelet alpha granule lumen
GO:0031143	pseudopodium
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome