InnateDB Protein
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IDBP-598678.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MPPE1
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Protein Name
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metallophosphoesterase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433950
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InnateDB Gene
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IDBG-1009 (MPPE1)
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Protein Structure
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Function |
Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins. {ECO:0000269PubMed:19837036}.
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Subcellular Localization |
Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:19837036}; Multi-pass membrane protein {ECO:0000269PubMed:19837036}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:19837036}; Multi- pass membrane protein {ECO:0000269PubMed:19837036}. Note=Also localizes to endoplasmic reticulum exit site.
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Disease Associations |
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Tissue Specificity |
Expressed in brain. {ECO:0000269PubMed:11978971}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004843
Calcineurin-like phosphoesterase domain, apaH type
IPR029052
Metallo-dependent phosphatase-like
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PFAM |
PF00149
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q53F39
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PhosphoSite |
PhosphoSite-Q53F39
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TrEMBL |
K7ESB8
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UniProt Splice Variant |
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Entrez Gene |
65258
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UniGene |
Hs.712666
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RefSeq |
XP_006722412
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HUGO |
HGNC:15988
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OMIM |
611900
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CCDS |
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HPRD |
14734
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IMGT |
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EMBL |
AF289560
AF363482
AF363483
AF363484
AK021647
AK023052
AK223450
AP001269
BC002877
BC073994
CH471113
EF444996
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GenPept |
AAH02877
AAH73994
AAL55744
AAM00277
AAM00278
AAM00279
ACA06017
ACA06018
ACA06019
BAB13863
BAB14378
BAD97170
EAX01562
EAX01564
EAX01565
EAX01567
EAX01568
EAX01569
EAX01571
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