InnateDB Protein
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IDBP-598738.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGPAT2
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Protein Name
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1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
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Synonyms
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1-AGPAT2; BSCL; BSCL1; LPAAB; LPAAT-beta;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000438919
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InnateDB Gene
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IDBG-92546 (AGPAT2)
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Protein Structure
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Function |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269PubMed:15629135, ECO:0000269PubMed:21873652, ECO:0000269PubMed:9242711}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:21873652}; Multi-pass membrane protein {ECO:0000269PubMed:21873652}.
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Disease Associations |
Congenital generalized lipodystrophy 1 (CGL1) [MIM:608594]: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. {ECO:0000269PubMed:11967537}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed predominantly in adipose tissue, pancreas and liver. {ECO:0000269PubMed:21873652}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003841
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1-acylglycerol-3-phosphate O-acyltransferase activity
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GO:0016746
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transferase activity, transferring acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002123
Phospholipid/glycerol acyltransferase
IPR004552
1-acyl-sn-glycerol-3-phosphate acyltransferase
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PFAM |
PF01553
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PRINTS |
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PIRSF |
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SMART |
SM00563
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TIGRFAMs |
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Modification |
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SwissProt |
O15120
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PhosphoSite |
PhosphoSite-O15120
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TrEMBL |
Q8WUW2
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UniProt Splice Variant |
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Entrez Gene |
10555
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UniGene |
Hs.320151
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RefSeq |
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HUGO |
HGNC:325
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OMIM |
603100
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CCDS |
CCDS7003
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HPRD |
04373
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IMGT |
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EMBL |
AF000237
AF011374
AL590226
BC000026
BC004529
BC019292
CH471090
U56418
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GenPept |
AAB58776
AAB64299
AAC51649
AAH00026
AAH04529
AAH19292
CAH71722
CAH71723
EAW88249
EAW88250
EAW88251
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