Version 5.4
Homo sapiens Protein: DEFB1
Summary
InnateDB Protein IDBP-5988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEFB1
Protein Name defensin, beta 1
Synonyms BD1; DEFB-1; DEFB101; HBD1;
Species Homo sapiens
Ensembl Protein ENSP00000297439
InnateDB Gene IDBG-5986 (DEFB1)
Protein Structure
UniProt Annotation
Function Has bactericidal activity. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002227 innate immune response in mucosa
GO:0002526 acute inflammatory response
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009617 response to bacterium
GO:0019731 antibacterial humoral response
GO:0033574 response to testosterone
GO:0045087 innate immune response (InnateDB)
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001855 Beta defensin type
PFAM PF00711
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P60022
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1672
UniGene
RefSeq NP_005209
HUGO HGNC:2766
OMIM 602056
CCDS CCDS5959
HPRD 03634
IMGT
EMBL BC033298 BC047677 U50930 U50931 U73945 X92744 Z50788
GenPept AAB49758 AAC51728 AAH33298 AAH47677 CAA63405 CAA90650

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca