Version 5.4
Homo sapiens Protein: KIF2B
Summary
InnateDB Protein IDBP-59880.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF2B
Protein Name kinesin family member 2B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000268919
InnateDB Gene IDBG-59878 (KIF2B)
Protein Structure
UniProt Annotation
Function Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. {ECO:0000269PubMed:17538014}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:17538014}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:17538014}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:17538014}. Note=Association with kinetochore is transient.
Disease Associations
Tissue Specificity Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level). {ECO:0000269PubMed:17538014}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007018 microtubule-based movement
GO:0007019 microtubule depolymerization
GO:0007067 mitotic nuclear division
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0051983 regulation of chromosome segregation
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N4N8
PhosphoSite PhosphoSite-Q8N4N8
TrEMBL
UniProt Splice Variant
Entrez Gene 84643
UniGene Hs.731336
RefSeq NP_115948
HUGO HGNC:29443
OMIM 615142
CCDS CCDS32685
HPRD 10053
IMGT
EMBL AC019315 AF333335 AK057272 BC033802
GenPept AAH33802 AAK20830 BAB71406

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca