InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRRM4

Summary

InnateDB Protein

IDBP-59889.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRRM4

Protein Name

serine/arginine repetitive matrix 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000267260

InnateDB Gene

IDBG-59887 (SRRM4)

Protein Structure

UniProt Annotation

Function

Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum. {ECO:0000269PubMed:12800201, ECO:0000269PubMed:19737518}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0007399	nervous system development
GO:0007605	sensory perception of sound
GO:0008380	RNA splicing
GO:0030154	cell differentiation
GO:0043484	regulation of RNA splicing