InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC34A1

Summary

InnateDB Protein

IDBP-59895.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC34A1

Protein Name

solute carrier family 34 (sodium phosphate), member 1

Synonyms

FRTS2; NAPI-3; NPHLOP1; NPT2; NPTIIa; SLC11; SLC17A2;

Species

Homo sapiens

Ensembl Protein

ENSP00000321424

InnateDB Gene

IDBG-59893 (SLC34A1)

Protein Structure

UniProt Annotation

Function

May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Nephrolithiasis/osteoporosis, hypophosphatemic, 1 (NPHLOP1) [MIM:612286]: A disease characterized by decreased renal phosphate absorption, renal phosphate wasting, hypophosphatemia, hyperphosphaturia, hypercalciuria, nephrolithiasis and osteoporosis. {ECO:0000269PubMed:12324554}. Note=The disease is caused by mutations affecting the gene represented in this entry.Fanconi renotubular syndrome 2 (FRTS2) [MIM:613388]: A disease due to a generalized dysfunction of the proximal kidney tubule resulting in decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency. {ECO:0000269PubMed:20335586}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Kidney and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015293	symporter activity
GO:0015321	sodium-dependent phosphate transmembrane transporter activity
GO:0030165	PDZ domain binding
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001503	ossification
GO:0001822	kidney development
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006817	phosphate ion transport
GO:0007584	response to nutrient
GO:0009100	glycoprotein metabolic process
GO:0010288	response to lead ion
GO:0032026	response to magnesium ion
GO:0032355	response to estradiol
GO:0033189	response to vitamin A
GO:0035864	response to potassium ion
GO:0042431	indole metabolic process
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0044341	sodium-dependent phosphate transport
GO:0045838	positive regulation of membrane potential
GO:0046686	response to cadmium ion
GO:0046689	response to mercury ion
GO:0046849	bone remodeling
GO:0051260	protein homooligomerization
GO:0055062	phosphate ion homeostasis
GO:0055085	transmembrane transport
GO:0060416	response to growth hormone
GO:0071107	response to parathyroid hormone
GO:0071248	cellular response to metal ion
GO:0071374	cellular response to parathyroid hormone stimulus
GO:0072350	tricarboxylic acid metabolic process
GO:0072734	cellular response to staurosporine
GO:0097066	response to thyroid hormone
GO:0097187	dentinogenesis
GO:1901128	gentamycin metabolic process
GO:1901652	response to peptide
GO:1901684	arsenate ion transmembrane transport
GO:2000120	positive regulation of sodium-dependent phosphate transport
GO:2000187	positive regulation of phosphate transmembrane transport

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031226	intrinsic component of plasma membrane
GO:0031526	brush border membrane
GO:0031988	membrane-bounded vesicle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm