InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TUBA1A

Summary

InnateDB Protein

IDBP-598963.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TUBA1A

Protein Name

tubulin, alpha 1a

Synonyms

B-ALPHA-1; LIS3; TUBA3;

Species

Homo sapiens

Ensembl Protein

ENSP00000439020

InnateDB Gene

IDBG-31211 (TUBA1A)

Protein Structure

UniProt Annotation

Function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Lissencephaly 3 (LIS3) [MIM:611603]: A classic type lissencephaly associated with psychomotor retardation and seizures. Features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem. {ECO:0000269PubMed:17584854}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at a high level in fetal brain. {ECO:0000269PubMed:17584854}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	207 [view]
Protein-Protein	207 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006457	protein folding
GO:0007017	microtubule-based process
GO:0030705	cytoskeleton-dependent intracellular transport
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding
GO:0051258	protein polymerization
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000217 Tubulin
IPR002452 Alpha tubulin
IPR002453 Beta tubulin
IPR002967 Delta tubulin
IPR003008 Tubulin/FtsZ, GTPase domain
IPR004057 Epsilon tubulin
IPR008280 Tubulin/FtsZ, C-terminal
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain

PFAM

PF00091
PF03953

PRINTS

PR01161
PR01162
PR01163
PR01224
PR01519

PIRSF

SMART

SM00864
SM00865

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt