Version 5.4
Homo sapiens Protein: COPS7A
Summary
InnateDB Protein IDBP-599010.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS7A
Protein Name COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000446039
InnateDB Gene IDBG-14886 (COPS7A)
Protein Structure
UniProt Annotation
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269PubMed:11285227, ECO:0000269PubMed:11337588, ECO:0000269PubMed:12628923, ECO:0000269PubMed:12732143, ECO:0000269PubMed:9535219}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:9535219}. Nucleus {ECO:0000269PubMed:9535219}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at high level in brain, heart and skeletal muscle. {ECO:0000269PubMed:12020345}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 79 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010388 cullin deneddylation
Cellular Component
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
Protein Structure and Domains
PDB ID
InterPro IPR000717 Proteasome component (PCI) domain
PFAM PF01399
PRINTS
PIRSF
SMART SM00088
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBW8
PhosphoSite PhosphoSite-Q9UBW8
TrEMBL F5H7C6
UniProt Splice Variant
Entrez Gene 50813
UniGene Hs.624025
RefSeq NP_001157565
HUGO HGNC:16758
OMIM
CCDS CCDS8558
HPRD 16736
IMGT
EMBL AB014764 AB033603 AC125494 AF193844 AF210052 AK001318 AK021721 AK022488 AK292621 BC011789 CH471116
GenPept AAF04307 AAF19205 AAH11789 BAA85390 BAA91620 BAB14052 BAB87805 BAF85310 BAG51042 EAW88745 EAW88747 EAW88748

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca