Version 5.4
Homo sapiens Protein: RNF103
Summary
InnateDB Protein IDBP-59907.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF103
Protein Name ring finger protein 103
Synonyms HKF-1; KF-1; KF1; ZFP-103; ZFP103;
Species Homo sapiens
Ensembl Protein ENSP00000237455
InnateDB Gene IDBG-408958 (RNF103)
Protein Structure
UniProt Annotation
Function Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. {ECO:0000269PubMed:10500182, ECO:0000269PubMed:18675248}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:18675248}; Multi-pass membrane protein {ECO:0000269PubMed:18675248}.
Disease Associations
Tissue Specificity Highly expressed in the normal cerebellum but not in the cerebral cortex. {ECO:0000269PubMed:9070305}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007417 central nervous system development
GO:0016567 protein ubiquitination
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR012336 Thioredoxin-like fold
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF13098
PF13192
PF13462
PF13905
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00237
PhosphoSite PhosphoSite-O00237
TrEMBL
UniProt Splice Variant
Entrez Gene 7844
UniGene Hs.733319
RefSeq NP_005658
HUGO HGNC:12859
OMIM 602507
CCDS CCDS33237
HPRD 03939
IMGT
EMBL AB052743 AC015971 BC035053 BC110333 D76444
GenPept AAH35053 AAI10334 AAX93079 BAA19739 BAB20900

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca