InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB2A

Summary

InnateDB Protein

IDBP-599164.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB2A

Protein Name

RAB2A, member RAS oncogene family

Synonyms

LHX; RAB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000431846

InnateDB Gene

IDBG-22906 (RAB2A)

Protein Structure

UniProt Annotation

Function

Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Subcellular Localization

Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:17081065}; Lipid-anchor {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Endoplasmic reticulum membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005765	lysosomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt