Version 5.4
Homo sapiens Protein: GYLTL1B
Summary
InnateDB Protein IDBP-599178.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GYLTL1B
Protein Name glycosyltransferase-like 1B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000432869
InnateDB Gene IDBG-41317 (GYLTL1B)
Protein Structure
UniProt Annotation
Function Glycosyltransferase which participates in glycosylation of alpha-dystroglycan. May carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. Has a higher activity toward alpha-dystroglycan than LARGE. {ECO:0000269PubMed:15661757, ECO:0000269PubMed:15752776}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at high level in placenta, pancreas and kidney compared to LARGE. Not expressed in brain. {ECO:0000269PubMed:15752776, ECO:0000269PubMed:15958417}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0008152 metabolic process
GO:0046716 muscle cell cellular homeostasis
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002495 Glycosyl transferase, family 8
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF01501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N3Y3
PhosphoSite PhosphoSite-Q8N3Y3
TrEMBL
UniProt Splice Variant
Entrez Gene 120071
UniGene Hs.86543
RefSeq NP_689525
HUGO HGNC:16522
OMIM 609709
CCDS CCDS31473
HPRD 13618
IMGT
EMBL AC068385 AF258588 AK092526 AK096021 BC037291 CH471064
GenPept AAG23791 AAH37291 BAC03909 BAC04675 EAW68021

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca