InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYCBP2

Summary

InnateDB Protein

IDBP-599233.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYCBP2

Protein Name

MYC binding protein 2

Synonyms

PAM;

Species

Homo sapiens

Ensembl Protein

ENSP00000444596

InnateDB Gene

IDBG-39526 (MYCBP2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis. {ECO:0000269PubMed:18308511}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9689053}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone. {ECO:0000269PubMed:9689053}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008045	motor neuron axon guidance
GO:0016567	protein ubiquitination
GO:0021785	branchiomotor neuron axon guidance
GO:0021952	central nervous system projection neuron axonogenesis
GO:0032880	regulation of protein localization
GO:0042177	negative regulation of protein catabolic process
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0051493	regulation of cytoskeleton organization

Cellular Component

GO:0005634	nucleus
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0030424	axon

Protein Structure and Domains

PDB ID

InterPro

IPR000408 Regulator of chromosome condensation, RCC1
IPR001841 Zinc finger, RING-type
IPR008979 Galactose-binding domain-like
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR012983 PHR
IPR014756 Immunoglobulin E-set
IPR016024 Armadillo-type fold
IPR017868 Filamin/ABP280 repeat-like

PFAM

PF00415
PF13639
PF14634
PF08005
PF00630

PRINTS

PR00633

PIRSF

SMART

SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt