InnateDB Protein
|
IDBP-599423.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NANOG
|
Protein Name
|
Nanog homeobox
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000435288
|
InnateDB Gene
|
IDBG-16534 (NANOG)
|
Protein Structure
|
|
Function |
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269PubMed:15983365, ECO:0000269PubMed:16000880, ECO:0000269PubMed:16391521}.
|
Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:15983365}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes. {ECO:0000269PubMed:12787504, ECO:0000269PubMed:12787505, ECO:0000269PubMed:14990856, ECO:0000269PubMed:15982323, ECO:0000269PubMed:16391521}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 156 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
156 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0003677
|
DNA binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0003714
|
transcription corepressor activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
|
PFAM |
PF00046
|
PRINTS |
|
PIRSF |
|
SMART |
SM00389
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9H9S0
|
PhosphoSite |
PhosphoSite-Q9H9S0
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
79923
|
UniGene |
Hs.635882
|
RefSeq |
NP_001284627
|
HUGO |
HGNC:20857
|
OMIM |
607937
|
CCDS |
CCDS73436
|
HPRD |
06397
|
IMGT |
|
EMBL |
AB093576
AK022643
AY230262
AY578089
CH471116
|
GenPept |
AAP49529
AAT81526
BAB14151
BAC76999
EAW88649
EAW88651
|
|
|