Version 5.4
Homo sapiens Protein: PHACTR3
Summary
InnateDB Protein IDBP-599426.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHACTR3
Protein Name phosphatase and actin regulator 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000442483
InnateDB Gene IDBG-83464 (PHACTR3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.
Disease Associations
Tissue Specificity Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL- 60 leukemia cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004864 protein phosphatase inhibitor activity
Biological Process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID
InterPro IPR004018 RPEL repeat
PFAM PF02755
PRINTS
PIRSF
SMART SM00707
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96KR7
PhosphoSite PhosphoSite-Q96KR7
TrEMBL
UniProt Splice Variant
Entrez Gene 116154
UniGene Hs.631200
RefSeq NP_001268436
HUGO HGNC:15833
OMIM 608725
CCDS CCDS42895
HPRD 10571
IMGT
EMBL AB098521 AB098522 AJ311122 AJ617581 AK098788 AK314493 AK316047 AL121908 AL357503 BC108303 BC117362 BC117364 CH471077
GenPept AAI08304 AAI17363 AAI17365 BAC82348 BAC82349 BAG37093 BAH14418 CAC67489 CAF04087 CAI22517 CAI22518 CAI23227 CAI23228 CAI23229 CAM28339 EAW75428 EAW75429 EAW75430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca