Version 5.4
Homo sapiens Protein: C3orf58
Summary
InnateDB Protein IDBP-59950.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C3orf58
Protein Name chromosome 3 open reading frame 58
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000320081
InnateDB Gene IDBG-59948 (C3orf58)
Protein Structure
UniProt Annotation
Function May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade. {ECO:0000269PubMed:23784961}.
Subcellular Localization Cytoplasmic vesicle, COPI-coated vesicle. Golgi apparatus. Secreted.
Disease Associations Note=Genetic variations in C3orf58 may be associated with susceptibility to autism.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0060038 cardiac muscle cell proliferation
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0030126 COPI vesicle coat
GO:0030137 COPI-coated vesicle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NDZ4
PhosphoSite PhosphoSite-Q8NDZ4
TrEMBL E7ET39
UniProt Splice Variant
Entrez Gene 205428
UniGene Hs.707239
RefSeq NP_775823
HUGO HGNC:28490
OMIM 612200
CCDS CCDS3130
HPRD 14559
IMGT
EMBL AC117379 AC117387 AK095161 AK294020 AK315082 BC037293
GenPept AAH37293 BAG37549 BAG52997 BAH11649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca