InnateDB Protein
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IDBP-59956.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANKRD13D
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Protein Name
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ankyrin repeat domain 13 family, member D
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000310874
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InnateDB Gene
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IDBG-59954 (ANKRD13D)
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Protein Structure
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Function |
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269PubMed:22298428}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:22298428}. Late endosome {ECO:0000269PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003903
Ubiquitin interacting motif
IPR021832
Ankyrin repeat domain-containing protein 13
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PFAM |
PF02809
PF11904
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PRINTS |
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PIRSF |
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SMART |
SM00726
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZTN6
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PhosphoSite |
PhosphoSite-Q6ZTN6
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TrEMBL |
B3KND9
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UniProt Splice Variant |
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Entrez Gene |
338692
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UniGene |
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RefSeq |
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HUGO |
HGNC:27880
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OMIM |
615126
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CCDS |
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HPRD |
17349
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IMGT |
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EMBL |
AK027313
AK057681
AK124721
AK126438
AP001885
BC044239
BC110419
BC121024
BC121025
CH471076
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GenPept |
AAH44239
AAI10420
AAI21025
AAI21026
BAC85932
BAC86550
BAG51301
BAG51952
EAW74584
EAW74585
EAW74586
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