Version 5.4
Homo sapiens Protein: BNC2
Summary
InnateDB Protein IDBP-599810.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BNC2
Protein Name basonuclin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000431516
InnateDB Gene IDBG-51747 (BNC2)
Protein Structure
UniProt Annotation
Function Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.
Subcellular Localization Nucleus {ECO:0000269PubMed:15081112}.
Disease Associations
Tissue Specificity Highly expressed in testis, uterus and small intestine, and weakly expressed in colon and prostate. Also expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa and HEK293 cells. Not detected in blood, thymus, spleen or Hep-G2 cells. {ECO:0000269PubMed:14988505, ECO:0000269PubMed:15081112}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZN30
PhosphoSite PhosphoSite-Q6ZN30
TrEMBL S4R351
UniProt Splice Variant
Entrez Gene 54796
UniGene Hs.733873
RefSeq
HUGO HGNC:30988
OMIM 608669
CCDS
HPRD 12274
IMGT
EMBL AK000050 AK025882 AK092247 AK131398 AL162418 AL449983 AL450003 AL450105 AY438376 DQ884933 DQ884934 DQ884940 DQ884944
GenPept AAR99389 ABI78982 ABI78983 ABI78988 ABI78991 BAA90908 BAB15269 BAC03837 BAD18545 CAM21221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca