InnateDB Protein
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IDBP-599945.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PAAF1
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Protein Name
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proteasomal ATPase-associated factor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441494
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InnateDB Gene
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IDBG-64021 (PAAF1)
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Protein Structure
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Function |
Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation. {ECO:0000269PubMed:15831487, ECO:0000269PubMed:17289585, ECO:0000269PubMed:22316138}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, with highest levels in kidney, brain and testis. {ECO:0000269PubMed:15831487}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
43
[view]
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Protein-Protein |
42
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
IPR020472
G-protein beta WD-40 repeat
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PFAM |
PF00400
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PRINTS |
PR00320
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BRP4
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PhosphoSite |
PhosphoSite-Q9BRP4
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TrEMBL |
F5H3I1
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UniProt Splice Variant |
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Entrez Gene |
80227
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UniGene |
Hs.635189
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RefSeq |
XP_005274366
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HUGO |
HGNC:25687
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OMIM |
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CCDS |
CCDS58157
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HPRD |
07761
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IMGT |
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EMBL |
AF087895
AK021910
AK222501
AK298258
AK316394
AP002770
BC006142
BC021541
BC028628
CH471076
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GenPept |
AAH06142
AAH21541
AAH28628
AAP97194
BAB13933
BAD96221
BAG60522
BAH14765
EAW74917
EAW74919
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