InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CITED2

Summary

InnateDB Protein

IDBP-599981.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CITED2

Protein Name

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

Synonyms

ASD8; MRG-1; MRG1; P35SRJ; VSD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000444198

InnateDB Gene

IDBG-97161 (CITED2)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269PubMed:11581164, ECO:0000269PubMed:12586840, ECO:0000269PubMed:15051727}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12586840, ECO:0000269PubMed:8901575, ECO:0000269PubMed:9887100}. Note=Colocalizes with EP300 in dot-like structures.

Disease Associations

Ventricular septal defect 2 (VSD2) [MIM:614431]: A common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death. {ECO:0000269PubMed:16287139}. Note=The disease is caused by mutations affecting the gene represented in this entry.Atrial septal defect 8 (ASD8) [MIM:614433]: A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. {ECO:0000269PubMed:16287139}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0046332	SMAD binding
GO:0050693	LBD domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0001841	neural tube formation
GO:0001843	neural tube closure
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0001944	vasculature development
GO:0001947	heart looping
GO:0002089	lens morphogenesis in camera-type eye
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002521	leukocyte differentiation
GO:0003151	outflow tract morphogenesis
GO:0003156	regulation of organ formation
GO:0003197	endocardial cushion development
GO:0003281	ventricular septum development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007368	determination of left/right symmetry
GO:0007417	central nervous system development
GO:0007422	peripheral nervous system development
GO:0007507	heart development
GO:0007530	sex determination
GO:0007569	cell aging
GO:0008283	cell proliferation
GO:0008584	male gonad development
GO:0009612	response to mechanical stimulus
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0021602	cranial nerve morphogenesis
GO:0022409	positive regulation of cell-cell adhesion
GO:0030325	adrenal gland development
GO:0030336	negative regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030851	granulocyte differentiation
GO:0034405	response to fluid shear stress
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035802	adrenal cortex formation
GO:0035914	skeletal muscle cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046697	decidualization
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048821	erythrocyte development
GO:0060136	embryonic process involved in female pregnancy
GO:0060349	bone morphogenesis
GO:0060411	cardiac septum morphogenesis
GO:0060412	ventricular septum morphogenesis
GO:0060971	embryonic heart tube left/right pattern formation
GO:0061156	pulmonary artery morphogenesis
GO:0061308	cardiac neural crest cell development involved in heart development
GO:0061371	determination of heart left/right asymmetry
GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986	left/right axis specification
GO:0071363	cellular response to growth factor stimulus
GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:2000020	positive regulation of male gonad development
GO:2001141	regulation of RNA biosynthetic process