Version 5.4
Homo sapiens Protein: MTUS2
Summary
InnateDB Protein IDBP-600085.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTUS2
Protein Name microtubule associated tumor suppressor candidate 2
Synonyms CAZIP; ICIS; KIAA0774; TIP150;
Species Homo sapiens
Ensembl Protein ENSP00000445403
InnateDB Gene IDBG-20476 (MTUS2)
Protein Structure
UniProt Annotation
Function Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269PubMed:19543227}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:19543227}. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.
Disease Associations
Tissue Specificity Detected in embryonic stem cells differentiating to cardiomyocytes. {ECO:0000269PubMed:19806667}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0042803 protein homodimerization activity
Biological Process
Cellular Component
GO:0005813 centrosome
GO:0005881 cytoplasmic microtubule
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5JR59
PhosphoSite PhosphoSite-Q5JR59
TrEMBL B4DWQ4
UniProt Splice Variant
Entrez Gene 23281
UniGene Hs.22287
RefSeq
HUGO HGNC:20595
OMIM
CCDS
HPRD 11108
IMGT
EMBL AB018317 AK293970 AK301633 AL160255 AL596092 AL596114 AL607144 BC032481 BC119654 BC119655 BC129985 BC150245
GenPept AAH32481 AAI19655 AAI19656 AAI29986 AAI50246 BAA34494 BAG57342 BAG63116 CAI39910 CAI39912 CAI40386 CAI40565 CAI40566 CAI41204

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca