InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNF1A

Summary

InnateDB Protein

IDBP-600148.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNF1A

Protein Name

HNF1 homeobox A

Synonyms

HNF-1A; HNF1; IDDM20; LFB1; MODY3; TCF-1; TCF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000440361

InnateDB Gene

IDBG-61093 (HNF1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 357 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	357 [view]
Protein-Protein	50 [view]
Protein-DNA	307 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0030073	insulin secretion
GO:0035623	renal glucose absorption
GO:0042593	glucose homeostasis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046323	glucose import
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR006899 Hepatocyte nuclear factor 1, N-terminal
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR023219 Hepatocyte nuclear factor 1, dimerisation domain

PFAM

PF04814
PF13413

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20823

PhosphoSite