Version 5.4
Homo sapiens Protein: MESDC2
Summary
InnateDB Protein IDBP-600238.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MESDC2
Protein Name mesoderm development candidate 2
Synonyms BOCA; MESD;
Species Homo sapiens
Ensembl Protein ENSP00000453430
InnateDB Gene IDBG-25939 (MESDC2)
Protein Structure
UniProt Annotation
Function Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. {ECO:0000269PubMed:15014448, ECO:0000269PubMed:17488095}.
Subcellular Localization Endoplasmic reticulum {ECO:0000269PubMed:15014448, ECO:0000269PubMed:17488095}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006457 protein folding
GO:0007498 mesoderm development
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR019330 Mesoderm development candidate 2
PFAM PF10185
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14696
PhosphoSite PhosphoSite-Q14696
TrEMBL
UniProt Splice Variant
Entrez Gene 23184
UniGene Hs.732380
RefSeq
HUGO HGNC:13520
OMIM 607783
CCDS CCDS32308
HPRD 12129
IMGT
EMBL AY359110 BC009210 BC012746 CH471136 D42039
GenPept AAH09210 AAH12746 AAQ89468 BAA07640 EAW99109 EAW99110

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca