InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHNO1

Summary

InnateDB Protein

IDBP-600347.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHNO1

Protein Name

chromosome 12 open reading frame 32

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000438590

InnateDB Gene

IDBG-12540 (RHNO1)

Protein Structure

UniProt Annotation

Function

Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. {ECO:0000269PubMed:21659603}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20811708}. Chromosome {ECO:0000269PubMed:20811708}. Note=Localizes to sites of DNA damage in a H2AX-independent manner.

Disease Associations

Tissue Specificity

Weakly expressed in testis, prostate, ovary, thymus and small intestine. Expressed strongly in breast cancer cells. {ECO:0000269PubMed:20811708}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000725	recombinational repair
GO:0034644	cellular response to UV
GO:0070318	positive regulation of G0 to G1 transition
GO:0071479	cellular response to ionizing radiation