Version 5.4
Homo sapiens Protein: ZBED6
Summary
InnateDB Protein IDBP-600487.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZBED6
Protein Name zinc finger, BED-type containing 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000447879
InnateDB Gene IDBG-547038 (ZBED6)
Protein Structure
UniProt Annotation
Function Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250UniProtKB:D2EAC2}. Nucleus, nucleolus {ECO:0000250UniProtKB:D2EAC2}. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus. {ECO:0000250UniProtKB:D2EAC2}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR003656 Zinc finger, BED-type
IPR008906 HAT dimerisation domain, C-terminal
IPR012337 Ribonuclease H-like domain
PFAM PF02892
PF05699
PRINTS
PIRSF
SMART SM00614
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P86452
PhosphoSite PhosphoSite-P86452
TrEMBL
UniProt Splice Variant
Entrez Gene 100381270
UniGene Hs.716666
RefSeq NP_001167579
HUGO HGNC:33273
OMIM 613512
CCDS CCDS55673
HPRD
IMGT
EMBL AC114402
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca