InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TDRD3

Summary

InnateDB Protein

IDBP-600496.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TDRD3

Protein Name

tudor domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000440190

InnateDB Gene

IDBG-36543 (TDRD3)

Protein Structure

UniProt Annotation

Function

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine- methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. {ECO:0000269PubMed:15955813, ECO:0000269PubMed:18632687, ECO:0000269PubMed:21172665}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules.

Disease Associations

Tissue Specificity

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:18664458}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0016568	chromatin modification
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0035145	exon-exon junction complex

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR002999 Tudor domain
IPR009060 UBA-like
IPR010304 Survival motor neuron
IPR013894 Domain of unknown function DUF1767
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote

PFAM

PF00627
PF00567
PF06003
PF08585

PRINTS

PIRSF

SMART

SM00333
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H7E2