InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNF1A

Summary

InnateDB Protein

IDBP-600663.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNF1A

Protein Name

HNF1 homeobox A

Synonyms

HNF-1A; HNF1; IDDM20; LFB1; MODY3; TCF-1; TCF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000438804

InnateDB Gene

IDBG-61093 (HNF1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 357 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	357 [view]
Protein-Protein	50 [view]
Protein-DNA	307 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0045893

positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR006897 Hepatocyte nuclear factor 1, beta isoform, C-terminal
IPR006898 Hepatocyte nuclear factor 1, alpha isoform C-terminal
IPR006899 Hepatocyte nuclear factor 1, N-terminal
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR023219 Hepatocyte nuclear factor 1, dimerisation domain

PFAM

PF00046
PF04812
PF04813
PF04814
PF13413

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite